Oligonucleotide synthesis, siRNA and more
Bioneer has long been a leading manufacturer of phosphoramidites and oligonucleotides and has extensive expertise and experience in these areas.
Bioneer is an ISO 9001:2000-certified company with all products being manufactured under strict ISO 9001:2000 standards.
Reactions in Synthetic Reactors
Bioneer has four 6,000 L capacity reactors for synthesizing four different nucleosides.
All nucleoside phosphoramidites are manufactured in 6,000 L reactors.
Each reactor has a capacity of up to 50 kg per batch.
Per annum total manufacturing capacity for nucleoside phosphoramidites is approximately 4 tons.
Purification of phosphoramidites
The resulting DNA nucleoside phosphoramidites are purified with column chromatography for purities of ≥99%.
Four sets of 400 L volume columns are utilized for the separation of each different nucleoside phosphoramidite.
The purified/crystallized nucleoside phosphoramidites are finally filtered and dried to yield the final product in powder form.
The process is carefully moisture-controlled to maintain less than 40 ppm water content after being dissolved in acetonitrile,
the solvent for oligonucleotide synthesis.
All PRODUCTS: FOR RESEARCH USE ONLY NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Products may be covered by pending or issued patents in certain countries.