Bioneer's core business has always been the manufacture of DNA and RNA in conventional and breakthrough ways.
When RNA interference (RNAi) was discovered, Bioneer was there to help provide researchers with the tools they need
to accomplish their experiments. Bioneer is currently the market leader in RNAi technology in Asia, and is launching
in North America this year. Our RNAi portfolio consists of six areas:
• Predesigned siRNA libraries
• PCR primers for knockdown validation
• Human validated siRNA libraries
• Human siRNA library sets and subsets
• Control siRNAs
• siRNA design and synthesis
All Bioneer's siRNAs are designed using our Turbo si-Designer software. This software identifies highly effective siRNA
target sites with remarkably high knockdown rates. Critical parameters including base composition, thermodynamic
instability and base preference are all considered in the design algorithm. siRNAs spanning SNP sites are removed and finally,
non-specific siRNAs are eliminated following homology searching by BLAST and Smith-Waterman algorithms. The result is an siRNA
with extraordinary knockdown efficiency and minimal off-target effects.We are so confident in our software that we
have the best guarantee in the industry – Buy three of our AccuTarget siRNAs, and if 2 of them don’t have knockdown
rates of at least 80%, we will replace them free of charge!
*Bioneer 80% Guarantee Policy
When a customer purchases 3 siRNAs for one target gene, Bioneer guarantees 80% reduction in the target mRNA level for at least 2 siRNAs. If less than 80% reduction is shown for more than 2 siRNAs, Bioneer will design and provide 2 new siRNAs free of charge.*
*Bioneer reserves the right to request the customer his/her supporting data inclusive of:
- Transfection efficiency data: With NC (AccuTarget™ Fluorescein-labeled Negative Control) and siRNA concentration at 100 nM each
- siRNA knockdown efficiency data: PC (AccuTarget™ GAPDH/GFP/Luciferase siRNA) and NC (AccuTarget™ Negative Control) at 100 nM each