For 5’-/3’-end or internal functionalization during oligo synthesis

Features of Amino linkers

• Amino linker products can be coupled with standard synthesis protocols, such as DNA monomer phosphoramidite coupling protocols.
• The primary amino group can be used for subsequent conjugation of a variety of reporter dyes or labels.
• The base-labile TFA-group is easily cleaved with concentrated ammonia during the cleavage and deprotection steps. Additional deprotection steps are not necessary.
• The DMT-group can be cleaved more conveniently than the MMT-group on the synthesis instrument with an acidic deblocking solution to enable on-support labeling protocols.
• The 5'-DMT amino linker can be treated with normal deprotection and cleavage methods.